UltraPlex mxIF (multiplex immunofluorescence) is a paradigm-shifting technology that addresses the needs of precision medicine
With UltraPlex mxIF Plus you can phenotype your tumor sample and identify infiltrating lymphocytes with two tissue sections in two hours. Want to additionally look at PD-L1 expression on APCs and tumor? Add another serial section, it still takes just two hours!
Cell IDx developed UltraPlex, a proprietary, modified hapten-based technology to address the need for unrestricted, simple, rapid, and simultaneous detection of multiple cellular markers in tissue sections. Our individual panels consist of four markers plus DAPI as a nuclear marker to enumerate total cell number. With UltraPlex Plus, tissue alignment of two or three sequential sections labeled with individual four-plex UltraPlex mxIF panels provides an unsurpassed capacity for cellular analysis, generating a comprehensive map of cellular composition, localization, and marker expression in situ.
The combination of Cell IDx’s cancer phenotyping panels with immune marker panels on serial sections can generate rapid, accurate information on tumor phenotype, infiltrating immune subpopulations, levels of marker expression per cell, and individual cellular localization in situ relative to other immune cells or tumor.
Immune Infiltration of Triple-Negative Breast Cancer